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Oral Drugs Related With Muscle Wasting and Sarcopenia

published by Ariadna Riera

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Oral drugs related with muscle wasting and sarcopenia. A review.
LL. campins; M Camps; A. Riera; E. Pleguezuelos; JC. Yebenes; M. Serra-Prat
Article:
What is SARCOPENIA? Experts definition.
"age-associated loss of skeletal muscle mass and function"
International Working Group on Sarcopenia.
"a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength  with a rise of adverse outcomes such as  disability, poor quality of life and death"
European Working Group on Sarcopenia in Older People (EWGSOP).
Immobility
Genetic influence
Inflamation
Nutricional deficiencies
Endocrine factors
SARCOPENIA
most important causes
Muscle atrophy occurs  when the rate of degradation exceeds the rate of muscle protein synthesis. Many drugs taken  regularly for common conditions may interact with some of these mechanisms, and may lead a harmful or beneficial effect on muscle mass and strength.
ORAL DRUGS associated to muscle function.
HARMFUL
BENEFICIAL
Statins
Sulfonylureas
Glinides
ACE inhibitors*  ARBs**
Biguanides Thiazolidinediones Incretines
Allopurinol Formeterol
Vitamin D
* ACE: angiotensin-converting enzims **ARBs: angiotensin receptor blockers
Key words: Sarcopenia-Muscle wasting- Angiotensin converting enzim inhibitors-Statins- Antidiabetic drugs - Vitamin D
Reference: Pharmacology 2017;99:1-8. DOI: 10.1159/000448247
Corresponding autor: Dr Lluis Campins [email protected]
Autor: @ricastariad